A steak sandwich topped with pizza sauce and sliced or crumbled mozzarella constitutes a pizza steak, which is often placed briefly in a pizza oven or under a broiler to melt and lightly brown the cheese. Some establishments offer sliced pepperoni as an optional topping, to make a pepperoni pizza steak.

A cheesesteak made with chicken is called a chicken cheesesteak. When served with buffalo wing sauce and blue cheese dressing, it is called a buffalo chicken cheesesteak. Other variations include a "cheesesteak hoagie" which contains lettuce and tomato.

The Reading, Pennsylvania headquartered, Steak-umm Company has long been known for its thin-sliced frozen steaks that are sold in supermarkets throughout the US and are used for making homemade Philadelphia-style cheesesteaks.The company claims to be "the best-known sandwich steak brand in America" and to have "helped turn the regional 'Philly Cheese Steak' Sandwich into standard fare on America's dinner tables over four decades ago".